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KMID : 0616120210520040257
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Korean Journal of Pharmacognosy
2021 Volume.52 No. 4 p.257 ~ p.266
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In vitro Anti-inflammatory Activities and Phenolic Acid Analysis of Tree Sprout Extracts
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Kim Ju-Ree
Quynh Nhu Nguyen
Shin Han-Na
Kang Ji-Sung
Lee Sang-Hyun
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Abstract
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This study evaluated several in vitro activities including the preliminary assessment of the anti-cancer, anti-inflammatory, and anti-diabetic effects of tree sprout extracts. Chlorogenic, caffeic, and p-coumaric acid contents in tree sprouts were analyzed using high-performance liquid chromatography and an ultraviolet detector. Among the studied tree sprout extracts, the ethanol (EtOH) extract of Rhus verniciflua exhibited the most potent anti-cancer effect by suppressing the cell viability of a human gastric adenocarcinoma cell line, with an IC50 of 7.06 μg/mL. The EtOH extract of Morus alba (MAB) inhibited the secretion of nitric oxide (NO) at a concentration of 100 μg/mL, with an IC50 of 83.44 μg/mL. Moreover, the EtOH extract of Securinega suffruticosa inhibited NO secretion with the lowest IC50 of 54.42 μg/mL. The EtOH extract of Fraxinus mandschurica was the only extract with effective α-glucosidase inhibitory activity. The total content of chlorogenic, caffeic, and p-coumaric acids was the highest in MAB (14.63 mg/g ext.). In conclusion, the beneficial activities of the tree sprout extracts with high phenolic acid content were generally high. Our results provide a theoretical basis for the development of health-promoting supplements and functional foods.
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KEYWORD
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Anti-cancer, Anti-inflammatory, Anti-diabetes, Phenolic acid, Tree sprout
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